{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:28:34Z","timestamp":1787005714279,"version":"build-2736575974"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"32","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"Public Health Service Award","award":["F32 AI133910"],"award-info":[{"award-number":["F32 AI133910"]}]},{"name":"Public Health Service Award","award":["R01 AI091707"],"award-info":[{"award-number":["R01 AI091707"]}]},{"name":"NCI, NIDA, and NIH","award":["R01CA101795"],"award-info":[{"award-number":["R01CA101795"]}]},{"name":"NCI, NIDA, and NIH","award":["DA030338"],"award-info":[{"award-number":["DA030338"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,8,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Malaria is a deadly disease affecting hundreds of millions of people. Cerebral malaria is a type of severe disease with a high mortality rate. However, the causes leading to cerebral malaria, likely including parasite and host factors, are still elusive. Here we discover and investigate a host gene (receptor transporter protein 4 [RTP4]) that can regulate host type I interferon responses and symptoms of experimental cerebral malaria. RTP4 also significantly affects West Nile virus load in the brains of infected mice, but not in the heart and the spleen. This study reveals important roles of RTP4 in antimalarial and antiviral immunity, particularly in brain infection and pathology. RTP4 is a potential target for therapy in some neurological diseases.<\/jats:p>","DOI":"10.1073\/pnas.2006492117","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T20:09:20Z","timestamp":1595621360000},"page":"19465-19474","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology"],"prefix":"10.1073","volume":"117","author":[{"given":"Xiao","family":"He","sequence":"first","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-1426","authenticated-orcid":false,"given":"Alison W.","family":"Ashbrook","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90027;"},{"name":"Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;"},{"name":"Norris Comprehensive Cancer Center, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-6160","authenticated-orcid":false,"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Heinrich","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-1320","authenticated-orcid":false,"given":"Lu","family":"Xia","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"},{"name":"Center for Medical Genetics, School of Life Sciences, Central South University, 410078 Changsha, Hunan, The People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chih","family":"Peng","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyla C.","family":"Tumas","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brajesh K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-feng","family":"Qi","sequence":"additional","affiliation":[{"name":"Pathology Core, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-5906","authenticated-orcid":false,"given":"Timothy G.","family":"Myers","sequence":"additional","affiliation":[{"name":"Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole A.","family":"Long","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-9225","authenticated-orcid":false,"given":"Chengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Transgenic Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8132"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children\u2019s Hospital of Los Angeles, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90027;"},{"name":"Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;"},{"name":"Norris Comprehensive Cancer Center, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3246-3248","authenticated-orcid":false,"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[{"name":"Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892-8132;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1311"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00775.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005118"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10776-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.12.010"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316467111"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3424"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141539"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70698"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.015"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005945"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005999"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2015.09.010"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02096-2"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102143"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005930"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903824"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3742"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00923-13"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.016"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701048"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1978"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2016.09.003"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041836"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506803102"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.06.058"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02161-16"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.156.5.1886","article-title":"Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction","volume":"156","author":"Schofield L.","year":"1996","unstructured":"L. Schofield ., Glycosylphosphatidylinositol toxin of Plasmodium up-regulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction. J. Immunol. 156, 1886\u20131896 (1996).","journal-title":"J. Immunol."},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413541200"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060889"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804106105"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M513637200"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.021"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09907"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-017-0583-3"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8861-z"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.05.004"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812909115"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep39258"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1212-8"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.756510"},{"key":"e_1_3_4_43_2","unstructured":"D. A. G. Pati\u00f1o The contribution of mast cells to antiviral immune responses: Characterization and functional definition of receptor transporter protein 4 (RTP4). PhD thesis Free University of Berlin. (2013). Available at https:\/\/d-nb.info\/1034527789\/34."},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.118.112987"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343327"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6416"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102261108"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2006492117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2006492117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T16:11:40Z","timestamp":1696435900000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2006492117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":47,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2020,8,11]]}},"alternative-id":["10.1073\/pnas.2006492117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2006492117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"assertion":[{"value":"2020-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}