{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:04:41Z","timestamp":1793657081955,"version":"4.5.1"},"reference-count":36,"publisher":"National Academy of Sciences","issue":"20","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008460","name":"HHS | NIH | National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R01AT009708"],"award-info":[{"award-number":["R01AT009708"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["F32GM126650"],"award-info":[{"award-number":["F32GM126650"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,5,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Microbes shape human health and disease. Today, there are increasing correlations of gut microbes with specific diseases, but the underlying molecules and mechanism linking the two are not known. This stifles both the understanding of disease causation and the development of suitable treatments. We investigated a dozen patient isolates of\n                    <jats:italic>Ruminococcus gnavus<\/jats:italic>\n                    , a prevalent gut microbe linked to inflammatory bowel disease (IBD). We found that some isolates possess a protective capsule that encourages a symbiotic relationship with the host immune system, while others lack this protective capsule and elicit a robust inflammatory immune response. This work reveals a path by which\n                    <jats:italic>R. gnavus<\/jats:italic>\n                    could be connected to IBD and potential therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2007595118","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T16:47:37Z","timestamp":1620665257000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":143,"title":["Capsular polysaccharide correlates with immune response to the human gut microbe\n                    <i>Ruminococcus gnavus<\/i>"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8325-6420","authenticated-orcid":false,"given":"Matthew T.","family":"Henke","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry &amp; Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9611-7438","authenticated-orcid":false,"given":"Chelsi D.","family":"Cassilly","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry &amp; Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hera","family":"Vlamakis","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramnik J.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114;"},{"name":"Broad Institute of MIT and Harvard, Cambridge, MA 02142;"},{"name":"Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0213-8356","authenticated-orcid":false,"given":"Jon","family":"Clardy","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry &amp; Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,5,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04612.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.041"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012615-044152"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030126"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.061"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.007"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223263"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0490-5"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214856"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08821"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.022"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau9356"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.09.001"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904099116"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuw006"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.50.2.583-585.1985"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01303-17"},{"key":"e_1_3_4_20_2","first-page":"931","article-title":"Structure of a new rhamnose polysaccharide, clostrhamnan, isolated from antitumor hot water extract of clostridium saccharoperbutylacetonicum cells","volume":"51","author":"Watanabe Y.","year":"1987","unstructured":"Y. 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