{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:51:19Z","timestamp":1792453879435,"version":"4.5.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"31","license":[{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["118186"],"award-info":[{"award-number":["118186"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>This study demonstrates that the extracellular protein human vitronectin (Vn) is able to bind both soluble calcium ions and mineralized hydroxyapatite with chemical specificity. The results have important implications for the normal functions of Vn and its role in the formation of plaques associated with age-related macular degeneration, Alzheimer\u2019s disease, atherosclerosis, and other degenerative disorders. The molecular basis for plaque formation in these pathologies is unknown. The present findings shed light on this important process, advance our understanding of the mechanisms of abnormal plaque formation, and introduce a target with potential for developing diagnostic, preventive, or therapeutic approaches.<\/jats:p>","DOI":"10.1073\/pnas.2007699117","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T20:06:01Z","timestamp":1595448361000},"page":"18504-18510","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Calcium and hydroxyapatite binding site of human vitronectin provides insights to abnormal deposit formation"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4836-8798","authenticated-orcid":false,"given":"Kyungsoo","family":"Shin","sequence":"first","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4856-525X","authenticated-orcid":false,"given":"James E.","family":"Kent","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-1329","authenticated-orcid":false,"given":"Chandan","family":"Singh","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-1501","authenticated-orcid":false,"given":"Lynn M.","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Yu","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-6041","authenticated-orcid":false,"given":"Wonpil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Chemistry, and Bioengineering, Lehigh University, Bethlehem, PA 18015"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-5844","authenticated-orcid":false,"given":"Francesca M.","family":"Marassi","sequence":"additional","affiliation":[{"name":"Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.12.003"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-24882"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00010-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.04.008"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000487053"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.835"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-3-16"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.3.477"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109703108"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413347112"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat4544"},{"key":"e_1_3_3_12_2","first-page":"269","article-title":"Vitronectin","volume":"10","author":"Tomasini B. R.","year":"1991","unstructured":"B. R. Tomasini, D. F. Mosher, Vitronectin. Prog. Hemost. Thromb. 10, 269\u2013305 (1991).","journal-title":"Prog. Hemost. Thromb."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1276590"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/iub.1203","article-title":"Vitronectin\u2013Master controller or micromanager?","volume":"65","author":"Leavesley D. I.","year":"2013","unstructured":"D. I. Leavesley ., Vitronectin\u2013Master controller or micromanager? IUBMB Life 65, 807\u2013818 (2013).","journal-title":"IUBMB Life"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06249.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi972247n"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26206"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07373.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5068"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.1.185.bloodjournal721185"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1247\/csf.13.123"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41995-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb943"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5766"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1006629"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317001061"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.735894"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0782473"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009219107"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02079"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1116\/1.4983407"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2005.08.020"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00058G"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00558-2"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02943"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-4655(98)00016-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi001567v"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)63024-X"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.03.023"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.13.4003"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8551"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103854108"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000179"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr800443h"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA17180B"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-016-0228-4"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1774"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.77.4.445"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2900"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-014-9893-4"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20449"},{"key":"e_1_3_3_53_2","volume-title":"Protein NMR Spectroscopy: Principles and Practice","author":"Cavanagh J.","year":"2007","unstructured":"J. Cavanagh, W. J. Fairbrother, A. G. Palmer, N. J. Skelton, Protein NMR Spectroscopy: Principles and Practice, J. Cavanagh, W. J. Fairbrother, A. G. Palmer, M. Rance, N. J. Skelton, Eds. (Academic Press, Burlington, ed. 2, 2007).","edition":"2"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1896"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1680062"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00497a058"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/00268979809483251"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn314"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2007699117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2007699117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T11:36:50Z","timestamp":1723289810000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2007699117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":60,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2020,8,4]]}},"alternative-id":["10.1073\/pnas.2007699117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2007699117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"2020-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}