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We hypothesized that metabolism is instrumental in host adaptation and compared the central metabolism of seven species. We demonstrate the existence of two distinct groups, including one overlapping with the classical zoonotic brucellae of domestic livestock that exclusively use the pentose phosphate pathway. Species from the second group rely mostly on the Entner\u2013Doudoroff pathway instead. This metabolic dichotomy arose after the acquisition of two newly identified EDP-inactivating mutations. This selected trait seems to be linked to bacterial pathogenicity in mice. The data fit the hypothesis that\n                    <jats:italic>Brucella<\/jats:italic>\n                    has undergone a stepwise metabolic evolution in domestic hosts that might also apply to other pathogens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2008939117","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T20:30:49Z","timestamp":1601929849000},"page":"26374-26381","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["Convergent evolution of zoonotic\n                    <i>Brucella<\/i>\n                    species toward the selective use of the pentose phosphate pathway"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-0011","authenticated-orcid":false,"given":"Arnaud","family":"Machelart","sequence":"first","affiliation":[{"name":"Research Unit in Biology of Microorganisms, Narilis, University of Namur, B-5000 Namur, Belgium;"},{"name":"Center for Infection and Immunity of Lille, Universit\u00e9 de Lille, CNRS, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1019, Unit\u00e9 Mixtes de Recherche 9017, 59000 Lille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-7947","authenticated-orcid":false,"given":"Kevin","family":"Willemart","sequence":"additional","affiliation":[{"name":"Research Unit in Biology of Microorganisms, Narilis, University of Namur, B-5000 Namur, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"Z\u00fa\u00f1iga-Ripa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Instituto de Salud Tropical, Instituto de Investigaci\u00f3n Sanitaria de Navarra, Universidad de Navarra, 31009 Pamplona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Godard","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Engineering, Technische Universit\u00e4t Braunschweig, 38106 Braunschweig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Plovier","sequence":"additional","affiliation":[{"name":"Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Universit\u00e9 Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7952-985X","authenticated-orcid":false,"given":"Christoph","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Institute of Systems Biotechnology, Universit\u00e4t des Saarlandes, 66123 Saarbr\u00fccken, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Moriy\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Instituto de Salud Tropical, Instituto de Investigaci\u00f3n Sanitaria de Navarra, Universidad de Navarra, 31009 Pamplona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-3043","authenticated-orcid":false,"given":"Xavier","family":"De Bolle","sequence":"additional","affiliation":[{"name":"Research Unit in Biology of Microorganisms, Narilis, University of Namur, B-5000 Namur, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-7647","authenticated-orcid":false,"given":"Emile","family":"Van Schaftingen","sequence":"additional","affiliation":[{"name":"De Duve Institute, UCLouvain, 1200 Brussels, Belgium;"},{"name":"WELBIO, UCLouvain, 1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-0224","authenticated-orcid":false,"given":"Jean-Jacques","family":"Letesson","sequence":"additional","affiliation":[{"name":"Research Unit in Biology of Microorganisms, Narilis, University of Namur, B-5000 Namur, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-7569","authenticated-orcid":false,"given":"Thibault","family":"Barbier","sequence":"additional","affiliation":[{"name":"Research Unit in Biology of Microorganisms, Narilis, University of Namur, B-5000 Namur, Belgium;"},{"name":"Department of Immunology and Infectious Diseases, Harvard T. 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