{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:49Z","timestamp":1792698109663,"version":"4.5.0"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"46","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal disease, primarily caused by germline mutation of\n                    <jats:italic>PKD1<\/jats:italic>\n                    or\n                    <jats:italic>PKD2<\/jats:italic>\n                    , leading to end-stage renal disease. There are few cures for ADPKD, although many researchers are trying to find a cure. The Hippo signaling pathway regulates organ growth and cell proliferation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a Hippo signaling effector. In this study, we demonstrated that the PKD1\u2013TAZ\u2013Wnt\u2013\u03b2-catenin\u2013c-MYC signaling axis plays a critical role in cystogenesis. Endo IWR1 treatment, which inhibited \u03b2-catenin activity via AXIN stabilization, reduced cyst growth in an ADPKD model. Our findings provide a potential therapeutic target against ADPKD and would be important for clinical translation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2009334117","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T20:20:24Z","timestamp":1604002824000},"page":"29001-29012","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["TAZ\/Wnt-\u03b2-catenin\/c-MYC axis regulates cystogenesis in polycystic kidney disease"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-1653","authenticated-orcid":false,"given":"Eun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ah","family":"Nam","sequence":"additional","affiliation":[{"name":"Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9764-4958","authenticated-orcid":false,"given":"Jaehee","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minah","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-6234","authenticated-orcid":false,"given":"Eek-hoon","family":"Jho","sequence":"additional","affiliation":[{"name":"Department of Life Science, University of Seoul, 02504 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hyun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8082-0214","authenticated-orcid":false,"given":"Jong Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Sookmyung Women\u2019s University, 04310 Seoul, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-3549","authenticated-orcid":false,"given":"Yong Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea;"},{"name":"Department of Internal Medicine, College of Medicine, The Catholic University of Korea, St. Vincent\u2019s Hospital, 16247 Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00201.x"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.101707.125712"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.05.002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.05.004"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102376"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3487"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701376RR"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2856"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.315127.118"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313707"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.80"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep31931"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010070774"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2010"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14083-8"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.137"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.013"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93725"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53061-0"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005894"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.3727\/105221617X15034976037343"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605266104"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00201.2007"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2652"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.04.001"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002715"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003380"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509109102"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.214"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312569200"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110955"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005770"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402063"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.692285"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.12.009"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199010"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.03.007"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0244-8"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204825"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95874"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2012.07.002"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn039"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313192110"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.029"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2009334117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:43:53Z","timestamp":1649832233000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2009334117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":45,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2020,11,17]]}},"alternative-id":["10.1073\/pnas.2009334117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2009334117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}