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U.S.A."],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The ability of HIV-1 to rapidly develop resistance against various therapeutics remains a roadblock to finding a cure. Here we propose that nanoparticle-based therapeutics that mimic HIV-1 target cells by presenting clusters of CD4, the HIV-1 receptor, could prevent effective viral escape. We show that CD4 multimerization on the nanoparticle dramatically enhanced the neutralization potency and breadth compared with conventional CD4-based reagents that present only one or two copies of CD4. The CD4 nanoparticles neutralized a range of diverse HIV-1 strains, including patient isolates resistant to multiple broadly neutralizing antibodies. This work describes a new therapeutic direction that exploits the need of HIV-1 to bind CD4 on target cells, thus warranting further investigation for the potential development of a cure.<\/jats:p>","DOI":"10.1073\/pnas.2010320117","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T20:25:36Z","timestamp":1595276736000},"page":"18719-18728","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-9568","authenticated-orcid":false,"given":"Magnus A. 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