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Efforts in harnessing the abscopal effect of RT could systemically eliminate metastatic lesions disseminated beyond the radiation field; however, success has been limited thus far, owing to an inadequate understanding of the underlying mechanisms and an absence of reliable biomarkers for early prediction. Here we demonstrate that noninvasive PET imaging of ICAM-1 expression confers predictive value for abscopal effect efficacy at an early stage. This strategy may also facilitate potential high-throughput screening of current or novel drugs to be used in combination with RT to achieve desired antitumor therapeutic outcomes that eliminate both primary and metastatic lesions.<\/jats:p>","DOI":"10.1073\/pnas.2010333118","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T15:40:28Z","timestamp":1617118828000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["ICAM-1 orchestrates the abscopal effect of tumor radiotherapy"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-499X","authenticated-orcid":false,"given":"Yang","family":"Zhao","sequence":"first","affiliation":[{"name":"Medical Isotopes Research Center, Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, 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