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We identify the shared and organ-specific transcriptomes of\n                    <jats:italic>Spn<\/jats:italic>\n                    , show that bacterial and host gene-expression profiles are highly distinct during asymptomatic colonization versus disease-causing infection, and demonstrate that\n                    <jats:italic>Spn<\/jats:italic>\n                    and host genes with high levels of expression contribute to pathogenesis or host defense, respectively, making them optimal targets for intervention.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2010428117","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T13:42:16Z","timestamp":1608126136000},"page":"33507-33518","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":66,"title":["An in vivo atlas of host\u2013pathogen transcriptomes during\n                    <i>Streptococcus pneumoniae<\/i>\n                    colonization 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