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New methods that could awaken the immune system, enhance T cells and antigen-presenting cells (APCs) trafficking, and relieve immunosuppression to treat cold tumors are urgently in need. Here, we first report a chemically ingenious nanocluster FS@PMPt assembly by fluorine\u2013fluorine interaction to regulate the immune process. The nanocluster not only increased the infiltration of immunopositive cells from the outside but also decreased the immunosuppressive cells from the inside to break the shackles of immunosuppression, which provides a promising paradigm for improving the anti\u2013cold tumor immunotherapy.<\/jats:p>","DOI":"10.1073\/pnas.2011297117","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T18:41:48Z","timestamp":1608144108000},"page":"32962-32969","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":65,"title":["Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4596-9603","authenticated-orcid":false,"given":"Zhaoting","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-9098","authenticated-orcid":false,"given":"Honghao","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-6988","authenticated-orcid":false,"given":"Chenggen","family":"Qian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-6189","authenticated-orcid":false,"given":"Minjie","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904022116"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-07728-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.06.006"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0246-1"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0007-y"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900927"},{"key":"e_1_3_4_7_2","first-page":"1900101","article-title":"Immunomodulatory nanosystems","volume":"6","author":"Feng X.","year":"2019","unstructured":"X. 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