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Here a multidisciplinary approach was used to map the glycan epitope of\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    serogroup A capsular polysaccharide, a component of marketed vaccines, with a monoclonal antibody capable of triggering human complement-mediated bactericidal killing. The epitope was found to be composed of a trisaccharide motif, in which acetylation moieties play a pivotal role in binding. This study will guide the design of improved vaccines and therapeutics.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2011385117","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T19:26:23Z","timestamp":1604690783000},"page":"29795-29802","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Structure of a protective epitope reveals the importance of acetylation of\n                    <i>Neisseria meningitidis<\/i>\n                    serogroup A capsular polysaccharide"],"prefix":"10.1073","volume":"117","author":[{"given":"Pedro","family":"Henriques","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"},{"name":"Research and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Dello Iacono","sequence":"additional","affiliation":[{"name":"Research and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-2605","authenticated-orcid":false,"given":"Ana","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Chemical Glycobiology Lab CIC bioGUNE Technology Park, 48160 Derio, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-5522","authenticated-orcid":false,"given":"Alessia","family":"Biolchi","sequence":"additional","affiliation":[{"name":"Research and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Romano","sequence":"additional","affiliation":[{"name":"Research and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Arda","sequence":"additional","affiliation":[{"name":"Chemical Glycobiology Lab CIC bioGUNE Technology Park, 48160 Derio, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gon\u04abalo J. 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