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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Enterotoxigenic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (ETEC), a leading cause of acute watery diarrheal illness in children, have also been linked to nondiarrheal sequelae including malnutrition. ETEC produce heat-labile toxin (LT) to stimulate the production of cellular cAMP, ultimately modulating ion channels to release salt and water into the intestinal lumen, resulting in diarrhea. Given the importance of cAMP as a \u201csecond messenger,\u201d we reasoned that cellular features could be altered by LT to benefit the bacteria. Interestingly, we found that LT-mediated increases in cAMP stimulate production of CEACAMs, a family of cell surface glycoproteins, which then serve as receptors for ETEC. Collectively, our findings may have implications for our understanding of toxin-mediated illness as well as sequelae associated with these important pathogens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2012480117","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T20:32:56Z","timestamp":1604349176000},"page":"29055-29062","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["CEACAMs serve as toxin-stimulated receptors for enterotoxigenic\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6978","authenticated-orcid":false,"given":"Alaullah","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunda","family":"Tumala","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8748-0761","authenticated-orcid":false,"given":"David","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-0982","authenticated-orcid":false,"given":"Matthew A.","family":"Ciorba","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3755-4763","authenticated-orcid":false,"given":"Taufiqur Rahman","family":"Bhuiyan","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB), Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdausi","family":"Qadri","sequence":"additional","affiliation":[{"name":"International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDRB), Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-6000","authenticated-orcid":false,"given":"Bernhard B.","family":"Singer","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University Duisburg-Essen, 45147 Essen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-697X","authenticated-orcid":false,"given":"James M.","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Molecular Microbiology and Microbial Pathogenesis Program, Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Medicine Service, Veterans Affairs Medical Center, St. Louis, MO 63106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30475-4"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60222-6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1093\/cid\/ciu653","article-title":"The MAL-ED study: A multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments","volume":"59","author":"MAL-ED Network Investigators","year":"2014","unstructured":"MAL-ED Network Investigators, The MAL-ED study: A multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. 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