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Using computational modeling we were able to identify chemicals that interact with the host factor that display broad-spectrum antiviral activity against influenza, coronaviruses, and filoviruses, all of which cause significant morbidity and mortality. Broad-spectrum antiviral therapeutics are sorely needed to combat known and unknown viral pathogens and the work presented here is our first step to developing antivirals to target the SKI complex.<\/jats:p>","DOI":"10.1073\/pnas.2012939117","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T20:25:44Z","timestamp":1605212744000},"page":"30687-30698","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-2953","authenticated-orcid":false,"given":"Stuart","family":"Weston","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 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