{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:28:14Z","timestamp":1791044894638,"version":"4.1.0"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,9,25]]},"abstract":"<jats:p>\n                    To investigate the role of retinal-based pigments (opsins) in\n circadian photoreception in mice, animals mutated in plasma retinol\n binding protein were placed on a vitamin A-free diet and tested for\n photic induction of gene expression in the suprachiasmatic nucleus.\n After 10 months on the vitamin A-free diet, the majority of mice\n contained no detectable retinal in their eyes. These mice demonstrated\n fully intact photic signaling to the suprachiasmatic nucleus as\n measured by acute\n                    <jats:italic>mPer<\/jats:italic>\n                    mRNA induction in the\n suprachiasmatic nucleus in response to bright or dim light. The data\n suggest that a non-opsin pigment is the primary circadian photoreceptor\n in the mouse.\n                  <\/jats:p>","DOI":"10.1073\/pnas.201301498","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:34:10Z","timestamp":1027679650000},"page":"11708-11713","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice"],"prefix":"10.1073","volume":"98","author":[{"given":"Carol L.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Blaner","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell N.","family":"Van Gelder","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Quadro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Colantuoni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max E.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Sancar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of North\r Carolina School of Medicine, Chapel Hill, NC 27599;\r Department of Medicine and Institute of\r Cancer Research, Columbia University College of Physicians and\r Surgeons, New York, NY 10032; Department of\r Ophthalmology and Visual Sciences, Washington University Medical\r School, St. Louis, MO 63110; and Faculty of Biological\r Sciences, University of Sannio, Benevento 82100, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,9,18]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(81)90651-4"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00198171"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)90304-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00225828"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5413.502"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00600.2000"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi962209o"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6097"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00167a001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.760"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-8777(99)00013-0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.31"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.33"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(00)01687-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1488"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81638-4"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006558"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5393.1490"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81014-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/19323"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.12114"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077094"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/074873040101600303"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00230-6"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.260498597"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.171.3976.1167"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00117-3"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.17.4633"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi990504d"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3867"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.18.4903"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619149"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80366-9"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80417-1"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80495-X"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80494-8"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.34.1.533"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.677"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.729"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01695-9"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1177\/074873099129000380"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80906-X"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1995.tb05231.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5427.553"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00259-7"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5440.768"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/35036078"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00353-4"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01122-0"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00277-X"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.201301498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:54:45Z","timestamp":1649832885000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.201301498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,18]]},"references-count":50,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2001,9,25]]}},"alternative-id":["10.1073\/pnas.201301498"],"URL":"https:\/\/doi.org\/10.1073\/pnas.201301498","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,18]]},"assertion":[{"value":"2001-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}