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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Many pathogens manipulate the host environment to promote their survival and eventual transmission.\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    , an intracellular parasite that can cause disease in those with weakened immune systems, is no exception. One of the more dramatic effects of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    infection on the host cell is a relocalization of the host mitochondria around the parasite-containing vacuole. Here, we have identified two host proteins that are required for\n                    <jats:italic>T. gondii<\/jats:italic>\n                    manipulation of host mitochondria, both of which are involved in mitochondrial protein import. This discovery is a remarkable example of a parasite gene evolving to specifically target a host receptor on the surface of an organelle.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2013336118","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T18:09:46Z","timestamp":1615831786000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["<i>Toxoplasma gondii<\/i>\n                    association with host mitochondria requires key mitochondrial protein import machinery"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-5976","authenticated-orcid":false,"given":"Matthew L.","family":"Blank","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-0042","authenticated-orcid":false,"given":"Mary M.","family":"Morcos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Sun","sequence":"additional","affiliation":[{"name":"Biomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-0375","authenticated-orcid":false,"given":"Pamela S.","family":"Cantrell","sequence":"additional","affiliation":[{"name":"Biomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-7942","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Biomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Biomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-8963","authenticated-orcid":false,"given":"Cameron J.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8P 5C2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Yates","sequence":"additional","affiliation":[{"name":"Biomedical Mass Spectrometry Center, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, PA 15261;"},{"name":"Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Boulanger","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8P 5C2;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-9243","authenticated-orcid":false,"given":"Jon P.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.4.1319"},{"key":"e_1_3_4_2_2","first-page":"356","article-title":"Morphological studies of the association of mitochondria with chlamydial inclusions and the fusion of chlamydial inclusions","volume":"40","author":"Matsumoto A.","year":"1991","unstructured":"A. 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