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Here, we present one strategy to overcome resistance to T cell\u2013based immunotherapies by pharmacologically modulating the STING pathway, a relatively common suppressed DNA-sensing pathway in human melanomas. We show that rescue of this pathway in human melanoma cells using a clinically available DNA methylation inhibitor can augment their antigenicity and recognition by tumor-infiltrating lymphocytes. These findings have important clinical implications for the development of optimal therapeutic protocols that consider the status of tumor-intrinsic STING activity and provide a strategy to design clinical interventions using T cell\u2013based immunotherapies with appropriate patient selection in melanoma.<\/jats:p>","DOI":"10.1073\/pnas.2013598118","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T16:40:48Z","timestamp":1617813648000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":189,"title":["Epigenetic reprogramming of tumor cell\u2013intrinsic STING function sculpts antigenicity and T cell recognition of melanoma"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-3807","authenticated-orcid":false,"given":"Rana","family":"Falahat","sequence":"first","affiliation":[{"name":"Department of Immunology, Moffitt Cancer Center, Tampa, FL 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