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EqHBV presumably originated in Africa, approximately at the time when donkey domestication started. EqHBV causes a hepatotropic disease comparable to human HBV infection and prolonged infections, resembling chronic hepatitis B in humans. In vitro infection studies suggested that horses are also susceptible to EqHBV. Both donkeys and horses also host a hepatitis C virus (HCV)-like virus. EqHBV offers unique opportunities for in vivo studies of both chronic hepatitis B and HBV\/HCV coinfections in terms of pathogenesis and therapy optimization.<\/jats:p>","DOI":"10.1073\/pnas.2013982118","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T18:00:23Z","timestamp":1615831223000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["A hepatitis B virus causes chronic infections in equids worldwide"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-1180","authenticated-orcid":false,"given":"Andrea","family":"Rasche","sequence":"first","affiliation":[{"name":"Institute of Virology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 10117 Berlin, Germany;"},{"name":"German Centre for Infection Research (DZIF), associated partner site Charit\u00e9, 10117 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