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Food safety is an immediate fear, and pathogenicity and potential for zoonotic transmission are important concerns. To find answers for those problems, we performed a pathogenicity study in young domestic pigs. We could demonstrate that young pigs develop severe respiratory disease upon RESTV infection and shed virus from mucosal membranes of the respiratory tract. We conclude that RESTV should be considered a livestock pathogen with zoonotic transmission impacting on animal and perhaps even human health.<\/jats:p>","DOI":"10.1073\/pnas.2015657118","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T11:55:09Z","timestamp":1608724509000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Reston virus causes severe respiratory disease in young domestic pigs"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-227X","authenticated-orcid":false,"given":"Elaine","family":"Haddock","sequence":"first","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Saturday","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Hanley","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7779-3059","authenticated-orcid":false,"given":"Atsushi","family":"Okumura","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"},{"name":"Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Lovaglio","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Long","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Thomas","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana P.","family":"Scott","sequence":"additional","affiliation":[{"name":"Rocky Mountain Veterinary Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla","family":"Pulliam","sequence":"additional","affiliation":[{"name":"Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen A.","family":"Richt","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine &amp; 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