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U.S.A."],"published-print":{"date-parts":[[2021,1,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Adenoviruses (AdVs) are DNA viruses that can cause severe respiratory illness in humans. A better understanding of the complex ways AdVs utilize cellular processes in service of their replication is critical to the development of new therapies to counter viral infection and disease. Using a genome-wide screen, we identified a cellular protein Mindbomb 1 (MIB1) required for AdV infection and show that it functions in the AdV entry process to mediate release of the viral genome into the nucleus. 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