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This mode of regulation of MC4R neurons could offer a new therapeutic avenue to modulate food intake and energy metabolism.<\/jats:p>","DOI":"10.1073\/pnas.2015990118","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T11:59:25Z","timestamp":1646567965000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-1761","authenticated-orcid":false,"given":"Yu","family":"Yong","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-7267","authenticated-orcid":false,"given":"Isin","family":"Cakir","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-6307","authenticated-orcid":false,"given":"Pauline","family":"Lining Pan","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7718-4782","authenticated-orcid":false,"given":"Jessica E.","family":"Biddinger","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2156-3497","authenticated-orcid":false,"given":"Rebecca J.","family":"Bluett","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-6199","authenticated-orcid":false,"given":"Ken","family":"Mackie","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences, Indiana University, Bloomington, IN 47405;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-0069","authenticated-orcid":false,"given":"Nathan","family":"Bingham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN 37232;"},{"name":"Department of Psychiatry &amp; Behavioral Sciences, Vanderbilt University Medical Center, Nashville TN 37232;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7222-8512","authenticated-orcid":false,"given":"Masoud","family":"Ghamari-Langroudi","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville TN 37232;"},{"name":"Warren Center for Neuroscience Drug Discovery, Department of Pharmacology, Vanderbilt University, Nashville TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6458"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(199912)26:4<397::AID-EAT5>3.0.CO;2-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800541"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62037-5"},{"key":"e_1_3_4_5_2","volume-title":"Managing Overweight and Obesity in Adults: Systematic Evidence Review from the Obesity Expert Panel, 2013. 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