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These parasites send a small number of proteins to infected blood cell surfaces, allowing them to bind host molecules but also risking their detection by the host immune system. These proteins have diversified into large families, allowing the parasite to avoid detection by using antigenic variation. The most ubiquitous of these families is the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    -interspersed repeat (PIR) protein family. Here we present the structure of a PIR protein, revealing the architecture of its ectodomain and showing how it has diversified. Finally, we use structure-guided methods to understand which small variant surface antigen families are PIRs and to understand their evolution across malaria parasites.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2016775117","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T20:34:32Z","timestamp":1606768472000},"page":"32098-32104","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Structure of the\n                    <i>Plasmodium<\/i>\n                    -interspersed repeat proteins of the malaria parasite"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-8484","authenticated-orcid":false,"given":"Thomas E.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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