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By comparing genome-wide expression differences between the two genomes in the same cell, we surmised that since the two species diverged from a common ancestor, natural selection has acted upon the expression level of an ancient metabolic pathway, illustrating that pathogenicity traits can arise over evolutionary timescales through small expression changes in deeply conserved proteins.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2016818118","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T18:07:12Z","timestamp":1615831632000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Lineage-specific selection and the evolution of virulence in the\n                    <i>Candida<\/i>\n                    clade"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-0989","authenticated-orcid":false,"given":"Sheena 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