{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:49:18Z","timestamp":1781110158226,"version":"3.54.1"},"reference-count":20,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NCI Intramural funds to MFK","award":["Intramural funding"],"award-info":[{"award-number":["Intramural funding"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,10,6]]},"DOI":"10.1073\/pnas.2017726117","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T20:42:16Z","timestamp":1600720936000},"page":"24614-24616","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":98,"title":["Low genetic diversity may be an Achilles heel of SARS-CoV-2"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-425X","authenticated-orcid":false,"given":"Jason W.","family":"Rausch","sequence":"first","affiliation":[{"name":"HIV Dynamics & Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-2115","authenticated-orcid":false,"given":"Adam A.","family":"Capoferri","sequence":"additional","affiliation":[{"name":"HIV Dynamics & Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702;"},{"name":"Microbiology and Immunology Department, Georgetown University, Washington, DC 20007"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-0600","authenticated-orcid":false,"given":"Mary Grace","family":"Katusiime","sequence":"additional","affiliation":[{"name":"HIV Dynamics & Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Patro","sequence":"additional","affiliation":[{"name":"HIV Dynamics & Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Kearney","sequence":"additional","affiliation":[{"name":"HIV Dynamics & Replication Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008281117"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.8.2.15013"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508200103"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2323"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000896"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2017.0141"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.12.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i1.126"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i36.4808"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa036"},{"key":"e_1_3_3_11_2","unstructured":"E. Weise 8 strains of the coronavirus are circling the globe. Here\u2019s what clues they\u2019re giving scientists. USA Today 27 March 2020. https:\/\/www.usatoday.com\/story\/news\/nation\/2020\/03\/27\/scientists-track-coronavirus-strains-mutation\/5080571002\/. Accessed 1 September 2020."},{"key":"e_1_3_3_12_2","unstructured":"N. Tingson Coronavirus Has THREE distinct strains according to study; US suffering from original variation. Tech Times 10 April 2020. https:\/\/www.techtimes.com\/articles\/248721\/20200410\/coronavirus-has-three-distinct-strains-according-to-study-us-suffering-from-original-variation.htm. Accessed 1 September 2020."},{"key":"e_1_3_3_13_2","article-title":"Coronavirus: Are there two strains and is one more deadly?","volume":"5","author":"Hamzelou J.","year":"2020","unstructured":"J. Hamzelou, Coronavirus: Are there two strains and is one more deadly? NewScientist, 5 March 2020. https:\/\/www.newscientist.com\/article\/2236544-coronavirus-are-there-two-strains-and-is-one-more-deadly\/. Accessed 1 September 2020.","journal-title":"NewScientist"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.043"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.012"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","unstructured":"L. Zhang . The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv:10.1101\/2020.06.12.148726 (12 June 2020).","DOI":"10.1101\/2020.06.12.148726"},{"key":"e_1_3_3_17_2","first-page":"e01098","article-title":"Naturally occurring single mutations in ebola virus observably impact infectivity","volume":"93","author":"Wong G.","year":"2018","unstructured":"G. Wong ., Naturally occurring single mutations in ebola virus observably impact infectivity. J. Virol. 93, e01098-18 (2018).","journal-title":"J. Virol."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12463"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.02.002"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2017726117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2017726117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:06:08Z","timestamp":1649829968000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2017726117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":20,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2020,10,6]]}},"alternative-id":["10.1073\/pnas.2017726117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2017726117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"2020-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}