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Blocking sugar uptake in\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    by selectively inhibiting the hexose transporter\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    hexose transporter 1 (PfHT1) kills the blood-stage parasites without affecting the host cells, making PfHT1 a promising therapeutic target. Here, we report the development of a series of small-molecule inhibitors that simultaneously target the orthosteric and the allosteric binding sites of PfHT1. These inhibitors all exhibit selective potency on the\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    strains over human cell lines. Our findings establish the basis for the rational design of next-generation antimalarial drugs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2017749118","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T15:18:29Z","timestamp":1609859909000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["Orthosteric\u2013allosteric dual inhibitors of PfHT1 as selective antimalarial agents"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-0425","authenticated-orcid":false,"given":"Jian","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, School of Pharmaceutical Sciences, Tsinghua University,100084 Beijing, China;"},{"name":"Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life 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