{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:54:55Z","timestamp":1781106895697,"version":"3.54.1"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["T32GM007276"],"award-info":[{"award-number":["T32GM007276"]}]},{"name":"NIH","award":["T32GM007365"],"award-info":[{"award-number":["T32GM007365"]}]},{"name":"NIH","award":["HHSN272201800004C"],"award-info":[{"award-number":["HHSN272201800004C"]}]},{"name":"NIH","award":["DP1DA043893"],"award-info":[{"award-number":["DP1DA043893"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Despite decades of research, an effective HIV-1 vaccine remains elusive. One potential vaccine target is the N-heptad repeat (NHR) region of gp41, which is the target of the FDA-approved drug enfuvirtide. However, monoclonal antibodies and antisera targeting this region have only been modestly neutralizing to date. Here, we show that the neutralization potency of the well-characterized anti-NHR antibody D5 is increased &gt;5,000-fold by expression of Fc\u03b3RI (CD64) on cells. Since Fc\u03b3RI is expressed on macrophages and dendritic cells, which are implicated in the early establishment of HIV-1 infection following sexual transmission, these results may be important to HIV-1 vaccine development.<\/jats:p>","DOI":"10.1073\/pnas.2018027118","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T16:15:01Z","timestamp":1610468101000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["The high-affinity immunoglobulin receptor Fc\u03b3RI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat"],"prefix":"10.1073","volume":"118","author":[{"given":"David C.","family":"Montefiori","sequence":"first","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, NC 27710;"},{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Filsinger Interrante","sequence":"additional","affiliation":[{"name":"Stanford Medical Scientist Training Program, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Stanford Biophysics Program, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Stanford ChEM-H, Stanford University, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-0173","authenticated-orcid":false,"given":"Benjamin N.","family":"Bell","sequence":"additional","affiliation":[{"name":"Stanford ChEM-H, Stanford University, Stanford, CA 94305;"},{"name":"Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3676-4283","authenticated-orcid":false,"given":"Adonis A.","family":"Rubio","sequence":"additional","affiliation":[{"name":"Stanford ChEM-H, Stanford University, Stanford, CA 94305;"},{"name":"Department of Biology, Stanford University School of Humanities and Sciences, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Joyce","sequence":"additional","affiliation":[{"name":"Vaccine Process Development, Merck &amp; Co., Inc., West Point, PA 19486;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Shiver","sequence":"additional","affiliation":[{"name":"Department of Vaccine Basic Research, Merck Research Laboratories, West Point, PA 19486;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia C.","family":"LaBranche","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, NC 27710;"},{"name":"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6503-4541","authenticated-orcid":false,"given":"Peter S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Stanford ChEM-H, Stanford University, Stanford, CA 94305;"},{"name":"Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Chan Zuckerberg Biohub, San Francisco, CA 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81430-0"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.70.1.777"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.03.043"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/3293"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1091"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.18.8859-8863.2001"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004261107"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.109"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.04.005"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301627200"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506927102"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1127"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001182"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078187"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001195"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02108-09"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00656-09"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00278-13"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.11.010"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-179754"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00020-07"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/156802611798808505"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003526"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.14.6710-6713.2001"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.8861-8869.2005"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01796-08"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02828"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042413"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-130070"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/v2081603"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00260"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.215"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.13.6087-6095.2000"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0703-847"},{"key":"e_1_3_4_35_2","first-page":"143","article-title":"The interaction of ruminant IgG with receptor type II for IgG on human phagocytes","volume":"66","author":"Jungi T. W.","year":"1989","unstructured":"T. W. Jungi, E. Peterhans, H. Pfister, H. Fey, The interaction of ruminant IgG with receptor type II for IgG on human phagocytes. Immunology 66, 143\u2013148 (1989).","journal-title":"Immunology"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02853-13"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.02.066"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03545.x"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00732"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1932"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00118"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.12.003"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.4709-4722.2002"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607302200"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908713106"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5443.1353"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004440"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.005"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3129"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02485"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02968"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01361-13"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.08.014"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01272-09"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008992"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00709-09"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01726-08"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1896-1905.2002"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.18.8358-8367.2000"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.4.2855-2864.1998"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01730-06"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00991-17"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-170-3_26"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.11.022"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030963"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.09.007"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","unstructured":"D. C. Montefiori . The high-affinity immunoglobulin receptor Fc\u03b3RI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat. bioRxiv:10.1101\/2020.08.27.271064 (28 August 2020).","DOI":"10.1101\/2020.08.27.271064"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2018027118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2018027118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T07:00:28Z","timestamp":1649833228000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2018027118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1,19]]}},"alternative-id":["10.1073\/pnas.2018027118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2018027118","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.27.271064","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"assertion":[{"value":"2021-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2018027118"}}