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U.S.A."],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>FGF23 is a circulating hormone produced in bone tissue that acts in the kidney to increase phosphate excretion and vitamin D metabolism essential for calcium absorption. Mutations that elevate FGF23 abundance cause autosomal dominant hypophosphatemic rickets or tumor-induced osteomalacia. Loss of FGF23, on the other hand, causes increased phosphate levels, such as in familiar tumor calcinosis. Here we show that the region in FGF23 responsible for KLA binding contains two distinct binding sites for KLA, demonstrating that FGF23 is able to simultaneously bind and assemble two KLA molecules. 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