{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:41:47Z","timestamp":1781239307802,"version":"3.54.1"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"51","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM099875"],"award-info":[{"award-number":["GM099875"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"HHS | NIH | National Human Genome Research Institute","doi-asserted-by":"publisher","award":["HG002898"],"award-info":[{"award-number":["HG002898"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK118250"],"award-info":[{"award-number":["DK118250"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Using a modified method, we analyzed single cells from adenocarcinomas of the colon, pancreas, and stomach and their paired normal tissues for somatic LINE-1 retrotransposition events. We found that somatic retrotransposition varied significantly from patient to patient with cancers of the same type, as well as in different cells within a particular cancer.<\/jats:p>","DOI":"10.1073\/pnas.2019450117","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T20:38:10Z","timestamp":1607114290000},"page":"32215-32222","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Striking heterogeneity of somatic L1 retrotransposition in single normal and cancerous gastrointestinal cells"],"prefix":"10.1073","volume":"117","author":[{"given":"Katsumi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha O.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loyal A.","family":"Goff","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Talasila","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungbin A.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Ivenitsky","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-9948","authenticated-orcid":false,"given":"Sadik","family":"Karma","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Brophy","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Devine","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-1052","authenticated-orcid":false,"given":"Stephen J.","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Haig H.","family":"Kazazian","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0831042100"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.021"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81998-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1662412"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.4.1429-1439.2001"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/74184"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1223"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/380207"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr245"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr863"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msv062"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1022"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03663"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10531"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08248"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.035"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.026"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4388"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.02.032"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.196238.115"},{"key":"e_1_3_4_22_2","first-page":"643","article-title":"Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer","volume":"52","author":"Miki Y.","year":"1992","unstructured":"Y. Miki ., Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer. Cancer Res. 52, 643\u2013645 (1992).","journal-title":"Cancer Res."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.020"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222077"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.145235.112"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1781"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.163659.113"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502474112"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23027"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251343"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0562-0"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12966"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28297"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-516-9_23"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1270"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.106419.110"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082089499"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.4.1385-1397.1988"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3919"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.218032.116"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.17.7780-7795.2005"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805404116"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg496"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.201814.115"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028373"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902645116"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.036"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.11.011"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601954103"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2326704"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.30058"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.02.036"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.050"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13100-016-0070-z"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2019450117","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2019450117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T06:10:41Z","timestamp":1649830241000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2019450117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":54,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2020,12,22]]}},"alternative-id":["10.1073\/pnas.2019450117"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2019450117","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"2020-12-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}