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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification occurs in cellular RNAs and viral transcripts and regulates the fate of cellular and viral RNAs. Hepatitis B virus (HBV) transcripts are m\n                    <jats:sup>6<\/jats:sup>\n                    A-methylated in the consensus DRACH motif in the epsilon stem\u2013loop, and this modification differentially regulates the viral life cycle depending on the m\n                    <jats:sup>6<\/jats:sup>\n                    A position at the 5\u2032- or 3\u2032-epsilon stem\u2013loop. Here, we report that HBV X (HBx) protein recruits cellular m\n                    <jats:sup>6<\/jats:sup>\n                    A machinery onto HBV minichromosome and host PTEN chromosomal locus to add m\n                    <jats:sup>6<\/jats:sup>\n                    A modification cotranscriptionally. Induced m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of HBV RNAs and PTEN mRNA by HBx decreases their stability. This study identifies the mechanism by which a viral protein regulates m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of RNA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2019455118","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T16:25:49Z","timestamp":1609777549000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral\/host RNAs"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-8268","authenticated-orcid":false,"given":"Geon-Woo","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5970-7535","authenticated-orcid":false,"given":"Aleem","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,1,4]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"2185","volume-title":"Fields Virology","author":"Seeger C.","year":"2013","unstructured":"C. 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