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U.S.A."],"published-print":{"date-parts":[[2020,12,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    We found that the probability of carrying heterozygous germline\n                    <jats:italic>BLM<\/jats:italic>\n                    mutations is significantly higher among mesothelioma patients than in the general population. In vitro and in vivo experiments suggest that heterozygous\n                    <jats:italic>BLM<\/jats:italic>\n                    mutations increase susceptibility to mesothelioma.\n                    <jats:italic>BLM<\/jats:italic>\n                    -mutation carriers are at higher risk of developing mesothelioma, and their risk increases upon asbestos exposure. Therefore,\n                    <jats:italic>BLM<\/jats:italic>\n                    mutation carriers should benefit from prevention and screening for early detection. We suggest that genetic testing to identify carriers of\n                    <jats:italic>BLM<\/jats:italic>\n                    heterozygous mutations and genetic counseling would help identify individuals at higher risk of mesothelioma and provide mutation carriers the option to implement simple preventive measures to reduce exposure to asbestos and other carcinogenic fibers to decrease their risk of developing mesothelioma.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2019652117","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T15:22:26Z","timestamp":1608132146000},"page":"33466-33473","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["Heterozygous germline\n                    <i>BLM<\/i>\n                    mutations increase susceptibility to asbestos and mesothelioma"],"prefix":"10.1073","volume":"117","author":[{"given":"Angela","family":"Bononi","sequence":"first","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 96813;"},{"name":"Department of Urology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 739-8511, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-193X","authenticated-orcid":false,"given":"Guntulu","family":"Ak","sequence":"additional","affiliation":[{"name":"Lung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University, 26040 Eskisehir, 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