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Our findings expand the molecular machinery required to build complex I from its constituent subunits and elucidates the function of a gene mutated in mitochondrial disease.<\/jats:p>","DOI":"10.1073\/pnas.2019665118","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T18:13:27Z","timestamp":1618942407000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["Optic atrophy\u2013associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-6151","authenticated-orcid":false,"given":"Luke E.","family":"Formosa","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-8478","authenticated-orcid":false,"given":"Boris","family":"Reljic","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;"},{"name":"Department of Biochemistry and Pharmacology, The Bio21 Institute, The University of Melbourne, VIC, 3000, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4162-2303","authenticated-orcid":false,"given":"Alice J.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-4420","authenticated-orcid":false,"given":"Daniella H.","family":"Hock","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, The Bio21 Institute, The University of Melbourne, VIC, 3000, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-6408","authenticated-orcid":false,"given":"Linden","family":"Muellner-Wong","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;"},{"name":"Department of Biochemistry and Pharmacology, The Bio21 Institute, The University of Melbourne, VIC, 3000, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-3383","authenticated-orcid":false,"given":"David A.","family":"Stroud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, The Bio21 Institute, The University of Melbourne, VIC, 3000, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-8829","authenticated-orcid":false,"given":"Michael T.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, VIC, 3800, Melbourne, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0124-1"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R117.809194"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170098"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.80"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.003"},{"key":"e_1_3_4_6_2","first-page":"650","article-title":"Nonsense mutation in TMEM126A causing autosomal recessive optic atrophy and auditory neuropathy","volume":"16","author":"Meyer E.","year":"2010","unstructured":"E. Meyer ., Nonsense mutation in TMEM126A causing autosomal recessive optic atrophy and auditory neuropathy. Mol. Vis. 16, 650\u2013664 (2010).","journal-title":"Mol. Vis."},{"key":"e_1_3_4_7_2","first-page":"1849","article-title":"TMEM126A mutation in a Moroccan family with autosomal recessive optic atrophy","volume":"18","author":"D\u00e9sir J.","year":"2012","unstructured":"J. D\u00e9sir ., TMEM126A mutation in a Moroccan family with autosomal recessive optic atrophy. Mol. Vis. 18, 1849\u20131857 (2012).","journal-title":"Mol. 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