{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:26:15Z","timestamp":1784899575548,"version":"3.55.0"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"3","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["F30DK112508"],"award-info":[{"award-number":["F30DK112508"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Eczema, hives, and allergic contact dermatitis affect millions of people every year, particularly children. Many skin allergies are caused by exaggerated production of type-2 cytokines, such as IL-4 and IL-13, by T helper (Th) cells in response to various substances when they contact the skin. Here, we illustrate that maladaptive Th2 responses to a cutaneous allergen can be recapitulated in a transgenic mouse model in which a subset of CD326\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells (DCs) that migrate from the skin to the draining lymph nodes are artificially depleted. This depletion perturbs the balance of DC subsets in lymph nodes, which biases T cell responses toward type-2 inflammation. Thus, preservation of lymph node CD326\n                    <jats:sup>+<\/jats:sup>\n                    DCs is essential to prevent or attenuate skin allergies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2021364118","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T09:44:30Z","timestamp":1610444670000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-2678","authenticated-orcid":false,"given":"Hannah L.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar Sairam","family":"Andhey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa K.","family":"Swiecki","sequence":"additional","affiliation":[{"name":"Discovery Immunology, Janssen Research &amp; Development, Spring House, PA 19477;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"McDonnell Genome Institute, Washington University, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Zaitsev","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Computer Technologies Department, ITMO University, St. Petersburg, Russia 197101;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7461-0408","authenticated-orcid":false,"given":"Alexandra-Chloe","family":"Villani","sequence":"additional","affiliation":[{"name":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-3436","authenticated-orcid":false,"given":"Makedonka","family":"Mitreva","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"McDonnell Genome Institute, Washington University, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim 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