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U.S.A."],"published-print":{"date-parts":[[2021,1,19]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>At active zones, ubiquitous proteins tether neurotransmitter-laden vesicles to specialized release sites, make them fusion-competent, and regulate their exocytotic fusion. Can specialized, synapse-specific proteins modulate this machinery? If so, which steps do they regulate? Here, we study mice lacking the presynaptic protein Mover. Mover is absent in some invertebrates and restricted to certain synapses in the rodent brain. Using electrophysiology and mathematical analysis of transmitter release kinetics at the calyx of Held, we find that Mover regulates a subset of fusion-competent synaptic vesicles: Mover selectively affects the vesicles most poised to be released during the initial stages of activity. Thus, by analogy, if ubiquitous proteins are light switches, Mover is a dimmer in transmitter release.<\/jats:p>","DOI":"10.1073\/pnas.2022551118","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T16:28:57Z","timestamp":1610468937000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["Regulation of a subset of release-ready vesicles by the presynaptic protein Mover"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8999-7406","authenticated-orcid":false,"given":"Ermis","family":"Pofantis","sequence":"first","affiliation":[{"name":"Institute of Anatomy and Embryology, University Medical Center G\u00f6ttingen, Georg-August University of G\u00f6ttingen, 37075 G\u00f6ttingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-7922","authenticated-orcid":false,"given":"Erwin","family":"Neher","sequence":"additional","affiliation":[{"name":"Emeritus Laboratory of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 G\u00f6ttingen, Germany;"},{"name":"Cluster of Excellence \u201cMultiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells,\u201d University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-4787","authenticated-orcid":false,"given":"Thomas","family":"Dresbach","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Embryology, University Medical Center G\u00f6ttingen, Georg-August University of G\u00f6ttingen, 37075 G\u00f6ttingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.012"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.022"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.013"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.092501.114547"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802104115"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606383113"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3553-05.2006"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15915"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0037-5"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0400-11.2011"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08452-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.017"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.024"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.070"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2018.00058"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.038"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80789-8"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/44565"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2008.10.068"},{"key":"e_1_3_4_20_2","article-title":"Non-negative matrix factorization as a tool to distinguish between synaptic vesicles in different functional states","author":"Neher E.","year":"2020","unstructured":"E. 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