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We showed that the bisamidinium-based compound DB213 specifically interacts with duplex CAG RNA; consequently, both\n                    <jats:italic>NUDT16<\/jats:italic>\n                    expression and DNA damage were rescued in HD mice. Our findings describe a pathogenic pathway that induces DNA damage in polyglutamine degeneration and demonstrate its therapeutic potential.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2022940118","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T16:18:24Z","timestamp":1620145104000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["CAG RNAs induce DNA damage and apoptosis by silencing\n                    <i>NUDT16<\/i>\n                    expression in polyglutamine degeneration"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-4727","authenticated-orcid":false,"given":"Shaohong","family":"Peng","sequence":"first","affiliation":[{"name":"Laboratory of Drosophila Research, The Chinese University of Hong Kong, Hong Kong, China;"},{"name":"School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, 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