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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Despite the relatively high disease burden of arenaviruses in South America and Africa, there are currently no Food and Drug Administration-approved drugs for use in preventing or treating any arenavirus infection. Currently, the sole clinically validated treatment option for Argentine hemorrhagic fever (AHF), caused by Junin virus (JUNV), is administration of immune plasma. While the relative success associated with this treatment supports passive immunotherapy interventions, the recent expansion of mAbs used in a clinical setting for infectious diseases offer a highly specific, consistently potent, and generally safe alternative to immune plasma. Here we show that a humanized mAb is highly efficacious in guinea pig and nonhuman primate models of AHF.<\/jats:p>","DOI":"10.1073\/pnas.2023332118","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T16:30:32Z","timestamp":1615221032000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":21,"title":["Therapy for Argentine hemorrhagic fever in nonhuman primates with a humanized monoclonal antibody"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-1024","authenticated-orcid":false,"given":"Larry","family":"Zeitlin","sequence":"first","affiliation":[{"name":"Mapp Biopharmaceutical, Inc., San Diego, CA 92121;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Cross","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan B.","family":"Geisbert","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoriya","family":"Borisevich","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-6935","authenticated-orcid":false,"given":"Krystle N.","family":"Agans","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-2077","authenticated-orcid":false,"given":"Abhishek N.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555;"},{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-012X","authenticated-orcid":false,"given":"Sven","family":"Enterlein","sequence":"additional","affiliation":[{"name":"Integrated BioTherapeutics, Inc., Gaithersburg, MD 20878"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-4707","authenticated-orcid":false,"given":"M. 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