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These stresses can have a devastating effect on agricultural productivity, and the appropriate responses of plants to stress are therefore critical. Autophagy is a macromolecular degradation pathway that is activated in response to stress, including ER stress, but the mechanism by which it is regulated is still unclear. Here, we describe a modification, persulfidation, of the key autophagy protein ATG18a that affects its binding to membranes and controls its activity. This tight regulation of autophagy therefore allows plants to control the tradeoff between growth and stress tolerance.<\/jats:p>","DOI":"10.1073\/pnas.2023604118","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T15:45:35Z","timestamp":1620747935000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":99,"title":["Persulfidation of ATG18a regulates autophagy under ER stress in\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-170X","authenticated-orcid":false,"given":"Angeles","family":"Aroca","sequence":"first","affiliation":[{"name":"Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011;"},{"name":"Institute of Plant Biochemistry and Photosynthesis, Consejo Superior de Investigaciones Cient\u00edficas, University of Seville, 41029 Seville, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-4720","authenticated-orcid":false,"given":"Inmaculada","family":"Yruela","sequence":"additional","affiliation":[{"name":"Estaci\u00f3n Experimental de Aula Dei, Consejo Superior de Investigaciones Cient\u00edficas, 50059 Zaragoza, Spain;"},{"name":"Group of Biochemistry, Biophysics, and Computational Biology (GBsC), BIFI-Unizar Joint Unit to CSIC, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-7446","authenticated-orcid":false,"given":"Cecilia","family":"Gotor","sequence":"additional","affiliation":[{"name":"Institute of Plant Biochemistry and Photosynthesis, Consejo Superior de Investigaciones Cient\u00edficas, University of Seville, 41029 Seville, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-9360","authenticated-orcid":false,"given":"Diane C.","family":"Bassham","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_3_5_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.01.001"},{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.2092"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13712"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/219625"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.02.006"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.101535"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1872886"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.3.14487"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0179-y"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.02.009"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.07.016"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318207111"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.34396"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.16.01582"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.20.00766"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2450748"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601623"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00303-2"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/ppl.13028","article-title":"Nitric oxide and hydrogen sulfide crosstalk during heavy metal stress in plants","volume":"168","author":"Shivaraj S. 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