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However, in this review, we summarize the evidence that people with acute COVID-19 and with ME\/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state. These phenomena have not yet been well studied in people with long COVID-19, and each of them has been reported in other diseases as well, particularly neurological diseases. We also examine the bidirectional relationship between redox imbalance, inflammation, energy metabolic deficits, and a hypometabolic state. We speculate as to what may be causing these abnormalities. Thus, understanding the molecular underpinnings of both PASC and ME\/CFS may lead to the development of novel therapeutics.<\/jats:p>","DOI":"10.1073\/pnas.2024358118","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T16:30:56Z","timestamp":1629131456000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":233,"title":["Redox imbalance links COVID-19 and myalgic encephalomyelitis\/chronic fatigue syndrome"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1862-6103","authenticated-orcid":false,"given":"Bindu D.","family":"Paul","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"},{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205;"},{"name":"The Solomon H. 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