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This study identifies a TTD-specific transcription deregulation of\n                    <jats:italic>PTGIS<\/jats:italic>\n                    (prostaglandin I\n                    <jats:sub>2<\/jats:sub>\n                    synthase) that results in reduced levels of prostaglandin I\n                    <jats:sub>2<\/jats:sub>\n                    . Reduced PTGIS is found in all TTD but not in XP patients, thus representing a biomarker for this disorder.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2024502118","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T16:40:23Z","timestamp":1624293623000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Reduced levels of prostaglandin I\n                    <sub>2<\/sub>\n                    synthase: a distinctive feature of the cancer-free trichothiodystrophy"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-0873","authenticated-orcid":false,"given":"Anita","family":"Lombardi","sequence":"first","affiliation":[{"name":"Istituto di Genetica Molecolare L.L. 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