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Here, we address this challenge by proposing a mechanism of PKA activation, distinct from the classical cAMP-dependent dissociation of the R\n                    <jats:sub>2<\/jats:sub>\n                    :C\n                    <jats:sub>2<\/jats:sub>\n                    complex and based on oligomerization of R1\u03b1 into assemblies, which are incompetent to inhibit PKA C.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2024716118","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T16:05:14Z","timestamp":1621353914000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex 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