{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:41:19Z","timestamp":1792132879177,"version":"4.4.0"},"reference-count":72,"publisher":"National Academy of Sciences","issue":"22","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["5U19MH104172"],"award-info":[{"award-number":["5U19MH104172"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"HHS | NIH | National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH122519"],"award-info":[{"award-number":["MH122519"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Heterozygous\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions predispose to schizophrenia and other neurodevelopmental disorders. Engineered heterozygous\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions impair neurotransmitter release in human neurons, suggesting a synaptic pathophysiological mechanism. In a multicenter effort to test the generality and robustness of this pivotal observation, we used, at two laboratories, independent analyses of patient-derived and newly engineered human neurons with heterozygous\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions. Schizophrenia patient-derived neurons with\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions exhibited the same major decrease in neurotransmitter release and an increase in CASK protein as engineered human neurons with\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions. Strikingly, engineered mouse\n                    <jats:italic>Nrxn1<\/jats:italic>\n                    -deficient neurons derived by the same method displayed no such phenotype, suggesting a human-specific role for\n                    <jats:italic>NRXN1<\/jats:italic>\n                    . Thus, heterozygous\n                    <jats:italic>NRXN1<\/jats:italic>\n                    deletions robustly impair synaptic function in human neurons, enabling future drug discovery efforts.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2025598118","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T16:15:56Z","timestamp":1621959356000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived\n                    <i>NRXN1<\/i>\n                    -mutant neurons"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-7665","authenticated-orcid":false,"given":"ChangHui","family":"Pak","sequence":"first","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Department of Biochemistry &amp; Molecular Biology, University of Massachusetts, Amherst, MA 01003;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-1508","authenticated-orcid":false,"given":"Tamas","family":"Danko","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent R.","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901;"},{"name":"Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-0676","authenticated-orcid":false,"given":"Jinzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2303-576X","authenticated-orcid":false,"given":"Yingfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-2689","authenticated-orcid":false,"given":"Madhuri","family":"Vangipuram","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-8553","authenticated-orcid":false,"given":"Sarah","family":"Grieder","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4082-8008","authenticated-orcid":false,"given":"Yu-Wen Alvin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-040X","authenticated-orcid":false,"given":"Kang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-6894","authenticated-orcid":false,"given":"Philip","family":"Dexheimer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bardes","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-5302","authenticated-orcid":false,"given":"Alexis","family":"Mitelpunkt","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 6997801;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-1271","authenticated-orcid":false,"given":"Junyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Fujifilm Cellular Dynamics, Inc., Madison, WI 53711;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Fujifilm Cellular Dynamics, Inc., Madison, WI 53711;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Rutgers University Cell and DNA Repository Infinite Biologics, National Institute of Mental Health Repository and Genomics Resource, Rutgers University, Piscataway, NJ 08854;"},{"name":"Department of Genetics, Rutgers University, Piscataway, NJ 08854;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-1615","authenticated-orcid":false,"given":"Carolin","family":"Purmann","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2192-1699","authenticated-orcid":false,"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN 46285;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Fujifilm Cellular Dynamics, Inc., Madison, WI 53711;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E.","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Aronow","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"},{"name":"Department of Pediatrics, University of Cincinnati, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping P.","family":"Pang","sequence":"additional","affiliation":[{"name":"Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901;"},{"name":"Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Levinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Wernig","sequence":"additional","affiliation":[{"name":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"S\u00fcdhof","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;"},{"name":"Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098918"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138659"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.07.022"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12259"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.039"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.59"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3725"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.113.131052"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv253"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0438-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2017.10.012"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.10.024"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.54"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13537"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0059-2"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12929"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4399"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.09.460"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.015"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz253"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01755"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.060"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4037"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.056"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.011"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.032"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103208"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.07.017"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.05.029"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.08.013"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2295"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08192"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2669"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","unstructured":"C. Pak . Rapid generation of functional and homogeneous excitatory human forebrain neurons using Neurogenin-2 (Ngn2). Protocol Exchange [Preprint] (2018). https:\/\/protocolexchange.researchsquare.com\/article\/nprot-6901\/v1 (Accessed 7 May 2021).","DOI":"10.1038\/protex.2018.082"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0219-17.2017"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013455"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03010"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.024"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.10.015"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.010"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059061"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1985"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.80"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/ajmg.b.31063","article-title":"Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders","volume":"153","author":"Ching M. S. L.","year":"2010","unstructured":"M. S. L. Ching .; Children\u2019s Hospital Boston Genotype Phenotype Study Group, Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 153B, 937\u2013947 (2010).","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201812076"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-08-02488.1996"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.07.021"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04264.2002"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81736-5"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.1.129"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.1.139"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.194"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0863-7"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03548.x"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10945"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11011"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.220"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3519"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/621690"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08797"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10202"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.028"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3428"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi165"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12975"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","unstructured":"T. Singh B. M. Neale M. J. Daly Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia. medRxiv [Preprint] (2020). https:\/\/doi.org\/10.1101\/2020.09.18.20192815 (Accessed 7 May 2021).","DOI":"10.1101\/2020.09.18.20192815"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2013.12.001"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25498"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.025"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107426"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.10.009"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2025598118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2025598118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T11:00:48Z","timestamp":1725102048000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2025598118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":72,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1073\/pnas.2025598118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2025598118","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.03.366617","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"2021-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2025598118"}}