{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:51:34Z","timestamp":1792291894863,"version":"4.4.0"},"reference-count":57,"publisher":"National Academy of Sciences","issue":"35","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES030576"],"award-info":[{"award-number":["ES030576"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES024373"],"award-info":[{"award-number":["ES024373"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["ES030546"],"award-info":[{"award-number":["ES030546"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) RNA methylation is the most-abundant modification in messenger RNA and noncoding RNA in eukaryotic cells. However, the regulatory and functional role of m\n                    <jats:sup>6<\/jats:sup>\n                    A in response to DNA damage remains poorly understood. Here, using the combination of in vitro models and mice with skin-specific genetic deletion of the key m\n                    <jats:sup>6<\/jats:sup>\n                    A writer factor METTL14, we have demonstrated a crucial role of METTL14 in global genome repair and ultraviolet B (UVB) radiation\u2013induced skin tumorigenesis. Such a role of METTL14 may serve as an emerging epitranscriptomic mechanism to coordinate RNA metabolism and UVB damage response in tumorigenesis. We anticipate that these findings may be translated into potential strategies to improve genome stability and cancer prevention by targeting the METTL14 pathway.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2025948118","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T15:36:06Z","timestamp":1630078566000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":102,"title":["METTL14 facilitates global genome repair and suppresses skin tumorigenesis"],"prefix":"10.1073","volume":"118","author":[{"given":"Zizhao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-7373","authenticated-orcid":false,"given":"Seungwon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-6521","authenticated-orcid":false,"given":"Yan-Hong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-6490","authenticated-orcid":false,"given":"Jiangbo","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"},{"name":"Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-2271","authenticated-orcid":false,"given":"Xiaolong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"},{"name":"Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"},{"name":"Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637;"},{"name":"HHMI, University of Chicago, Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.073723"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12477095"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/12.5.861"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1652"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2663"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.7.1239"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.02.003"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077232"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.426"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm282"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.083022"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.08.010"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.035"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2009.05.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1908"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201106074"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12406"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky239"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh085"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20065"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.05.030"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003940"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.390"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.132"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1646"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3785"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12730"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.151"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.014"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.012"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14281"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay6018"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2017.03.002"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.08.030"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0034-6"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/php.12930"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.004"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature21671"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.031"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2245"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.023"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.415224"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13011209"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200507002"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702824200"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.3.14487"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.001"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.05.041"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800719R"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.11.016"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020360"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2017.1380757"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1432"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2902"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2025948118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2025948118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:07:10Z","timestamp":1649837230000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2025948118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":57,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2021,8,31]]}},"alternative-id":["10.1073\/pnas.2025948118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2025948118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"2021-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2025948118"}}