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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,5,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    RAS proteins (HRAS, NRAS, and KRAS) integrate extracellular trophic signals to promote cell proliferation. Constitutively active KRAS drives tumor initiation and progression in nonsmall cell lung cancer (NSCLC). As RAS proteins are often refractory to direct pharmacological inhibition, RAS-interacting proteins are under investigation as potential drug targets. We previously found Argonaute 2 (AGO2) to bind RAS and positively regulate RAS-dependent signaling pathways.\n                    <jats:italic>AGO2<\/jats:italic>\n                    knockdown blunted proliferation in NSCLC cells containing a KRAS-activating mutation. Here, we demonstrate that AGO2 promotes tumor progression in multiple mouse models of KRAS-driven NSCLC. In these animals,\n                    <jats:italic>Ago2<\/jats:italic>\n                    knockout impairs tumor growth, lowers pathologic grade, and inhibits KRAS signaling. Targeting the AGO2-KRAS interaction may hold future therapeutic promise in NSCLC and other KRAS-driven malignancies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2026104118","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T17:11:13Z","timestamp":1620666673000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["AGO2 promotes tumor progression in KRAS-driven mouse models of non\u2013small cell lung cancer"],"prefix":"10.1073","volume":"118","author":[{"given":"Jean Ching-Yi","family":"Tien","sequence":"first","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109;"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Chugh","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, 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