{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:25:15Z","timestamp":1792092315717,"version":"4.4.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"27","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000875","name":"Pew Charitable Trusts","doi-asserted-by":"publisher","award":["00027358"],"award-info":[{"award-number":["00027358"]}],"id":[{"id":"10.13039\/100000875","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Susceptibility (S) genes are plant genes that facilitate pathogen infection. Inactivation of S genes has been considered a promising strategy to obtain broad-spectrum and durable resistance in crops. We characterized two orthologs of the\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    S gene\n                    <jats:italic>DMR6<\/jats:italic>\n                    in tomato:\n                    <jats:italic>SlDMR6-1<\/jats:italic>\n                    and\n                    <jats:italic>SlDMR6-2<\/jats:italic>\n                    . We show that SlDMR6-1, but not SlDMR6-2, is associated with plant immunity. Remarkably,\n                    <jats:italic>Sldmr6-1<\/jats:italic>\n                    mutants display enhanced resistance to bacterial, oomycete, and fungal pathogens. This phenotype correlates with increased levels of the defense hormone salicylic acid (SA) and enhanced transcriptional activation of plant immune responses. We also demonstrate that SlDMR6-1 and SlDMR6-2 convert SA into its inactive form, 2,5-DHBA, indicating that they play a role in SA homeostasis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2026152118","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T17:37:13Z","timestamp":1625247433000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":228,"title":["Loss of function of a DMR6 ortholog in tomato confers broad-spectrum disease resistance"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-8714","authenticated-orcid":false,"given":"Daniela Paula de Toledo","family":"Thomazella","sequence":"first","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720;"},{"name":"Innovative Genomics Institute, University of California, Berkeley, CA 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