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Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates in anesthesia and after brain damage that causes disorders of consciousness. However, the neurochemical underpinnings of this network change remain largely unknown. Motivated by preclinical animal work and clinical observations, we found that across pharmacological (sedation) and pathological (disorders of consciousness) consciousness perturbation, the dopaminergic source nucleus, the ventral tegmental area, disconnects from the main nodes of the default mode network. As the severity of this dopaminergic disconnection was associated with default mode network disintegration, we propose that dopaminergic modulation may be a central mechanism for consciousness maintenance.<\/jats:p>","DOI":"10.1073\/pnas.2026289118","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T17:00:35Z","timestamp":1627059635000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation"],"prefix":"10.1073","volume":"118","author":[{"given":"Lennart R. 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