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U.S.A."],"published-print":{"date-parts":[[2021,7,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Despite improved understanding of cellular and molecular events mediating type 2 immune responses in the gut, how these changes facilitate worm expulsion remains largely unknown. We identified pyroptosis-effector gasdermin C genes (\n                    <jats:italic>Gsdmc<\/jats:italic>\n                    s) as type 2 cytokine-regulated target genes in intestinal epithelial cells. Furthermore, we showed that overexpression of Gsdmc2 triggered pyroptosis. Organoid cultures and in vivo mouse models were used to show that activating type 2 immunity leads to lytic cell death in gut epithelium and cleavage of Gsdmcs. We thus revealed a role of gasdermin-mediated lytic cell death in worm-induced type 2 immunity. Parasitic infection often leads to malnutrition and retarded growth; since this may involve villus atrophy, gasdermin activity may provide a pharmaceutical target for treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2026307118","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T15:25:12Z","timestamp":1626881112000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-1348","authenticated-orcid":false,"given":"Ranhui","family":"Xi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan 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