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U.S.A."],"published-print":{"date-parts":[[2021,3,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. It was originally characterized as a sensor, responding to environmental pollutants and inducing enzymes able to eliminate toxins. AhR is now known to be activated by endogenous ligands as well, such as the tryptophan metabolite, kynurenine. Its activation regulates numerous cell functions, including immunity and proliferation, that impact multiple diseases, such as cancer and infection. Here we show that AhR is activated following infection with human cytomegalovirus (HCMV). Its activation impacts both viral and cellular gene expression. Of note, AhR induces a cell cycle block, providing a mechanistic explanation for a long-known consequence of infection that is believed to reserve metabolic resources for the virus by preventing cellular proliferation.<\/jats:p>","DOI":"10.1073\/pnas.2026336118","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T18:18:39Z","timestamp":1615832319000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1\/S block to cell cycle progression"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-6729","authenticated-orcid":false,"given":"Pooya","family":"Naseri-Nosar","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 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Shenk P. Naseri-Nosar Differential genome expression in AhR-KD and control HCMV-infected fibroblasts. National Center for Biotechnology Information Gene Expression Omnibus. https:\/\/ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE159375. 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