{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:41:21Z","timestamp":1788921681412,"version":"build-2803163510"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,10,14]]},"abstract":"<jats:p>\n                    Strabismus has been known to have a significant genetic component, but the mode of inheritance and the identity of the relevant genes have been enigmatic. This paper reports linkage analysis of nonsyndromic strabismus. The principal results of this study are: (\n                    <jats:italic>i<\/jats:italic>\n                    ) the demonstrated feasibility of identifying and recruiting large families in which multiple members have (or had) strabismus; (\n                    <jats:italic>ii<\/jats:italic>\n                    ) the linkage in one large family of a presumptive strabismus susceptibility locus to 7p22.1 with a multipoint logarithm of odds score of 4.51 under a model of recessive inheritance; and (\n                    <jats:italic>iii<\/jats:italic>\n                    ) the failure to observe significant linkage to 7p in six other multiplex families, consistent with genetic heterogeneity among families. These findings suggest that it will be possible to localize and ultimately identify strabismus susceptibility genes by linkage analysis and mutation screening of candidate genes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2035118100","type":"journal-article","created":{"date-parts":[[2003,10,14]],"date-time":"2003-10-14T15:05:46Z","timestamp":1066143946000},"page":"12283-12288","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":37,"title":["A strabismus susceptibility locus on chromosome 7p"],"prefix":"10.1073","volume":"100","author":[{"given":"Vaishali","family":"Parikh","sequence":"first","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin Yao","family":"Shugart","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly F.","family":"Doheny","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Williams","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hayden","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Craig","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Capo","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Chamblee","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Collins","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Dankner","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Fiergang","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Guyton","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hunter","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Keys","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Morrison","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Munoz","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall","family":"Parks","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Plotsky","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Protzko","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael X.","family":"Repka","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Sarubbi","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Schnall","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Siatkowski","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Traboulsi","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Waeltermann","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Nathans","sequence":"additional","affiliation":[{"name":"Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology, and Howard Hughes Medical Institute, Center for Inherited Disease Research, Institute of Genetic Medicine, and Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33101; Suite 204, 606 Denrigh Boulevard, Newport..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,9,30]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"von Noorden G. (1996) Binocular Vision and Ocular Motility: Theory and Management of Strabismus (Mosby St. Louis) 5th Ed."},{"key":"e_1_3_2_2_2","unstructured":"Francois J. (1961) in Heredity in Ophthalmology (Mosby St. Louis) pp. 255\u2013269."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00151815"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/13816819409056905"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1755-3768.1939.tb07376.x","volume":"17","year":"1939","unstructured":"Holm, S. (1939) Acta Ophthalmol. 17, 367\u2013387.","journal-title":"Acta Ophthalmol."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2307\/4585018"},{"key":"e_1_3_2_7_2","unstructured":"Ing M. & Pang S. W. (1978) in Strabismus: Proceedings of the Third Meeting of the International Strabismological Association (Grune and Stratton New York) pp. 107\u2013110."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1956.00930030459002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.24.10.584"},{"key":"e_1_3_2_10_2","unstructured":"Richter S. (1967) Untersuchungen uber die Hereditat des Strabismus Concomitants (VEB Georg Thieme Leipzig Germany)."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130731018"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1755-3768.1964.tb03667.x","volume":"42","year":"1964","unstructured":"Nordlow, W. (1964) Acta Ophthalmol. 42, 1015\u20131037.14247244","journal-title":"Acta Ophthalmol."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1969.00990010755001"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3928\/0191-3913-19940901-06"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.61.1.27"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1952.01700030004001"},{"key":"e_1_3_2_17_2","first-page":"549","volume":"26","year":"1974","unstructured":"Hegmann, J. P., Mash, A. J. & Spivey, B. E. (1974) Am. J. Hum. Genet. 26, 549\u2013562.4424621","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_18_2","first-page":"85","volume":"84","year":"1986","unstructured":"Maumenee, I. H., Alston, A., Mets, M. B., Flynn, J. T., Mitchell, T. N. & Beatty, T. H. (1986) Trans. Am. Ophthalmol. Soc. 84, 85\u201393.3590483","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02808.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng744"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81242-8"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3368\/aoj.51.1.67"},{"key":"e_1_3_2_23_2","unstructured":"Young A. (1998) GAS Package (Oxford University Oxford) Version 2.3."},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/302112"},{"key":"e_1_3_2_25_2","first-page":"1347","volume":"58","year":"1996","unstructured":"Kruglyak, L., Daly, M. J., Reeve-Daly, M. P. & Lander, E. S. (1996) Am. J. Hum. Genet. 58, 1347\u20131363.8651312","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/302861"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.2.573"},{"key":"e_1_3_2_28_2","unstructured":"Ott J. (1991) Analysis of Human Genetic Linkage (Johns Hopkins Univ. Press Baltimore) 2nd Ed."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.11.3443"},{"key":"e_1_3_2_30_2","unstructured":"Duffy D. L. (1999) SIB-PAIR (Queensland Institute of Medical Research Brisbane Australia) Version 0.99.7."},{"key":"e_1_3_2_31_2","first-page":"1323","volume":"58","year":"1996","unstructured":"Sobel, E. & Lange, K. (1996) Am. J. Hum. Genet. 58, 1323\u20131337.8651310","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_3_2_32_2","first-page":"99","volume":"81","year":"2003","unstructured":"Shugart, Y. Y., Feng, B. J. & Collins, A. (2003) J. Genet. 81, 99\u2013103.","journal-title":"J. Genet."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2035118100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T19:24:44Z","timestamp":1704914684000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2035118100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,30]]},"references-count":32,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2003,10,14]]}},"alternative-id":["10.1073\/pnas.2035118100"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2035118100","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,30]]},"assertion":[{"value":"2003-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}