{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:23:20Z","timestamp":1783034600652,"version":"3.54.6"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"46","license":[{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    In this study, we show that the inactivation of the\n                    <jats:italic>gli3<\/jats:italic>\n                    gene in medaka fish results in the formation of larger dorsal and paired fins. These mutant fins display multiple radial bones and fin rays which resemble polydactyly in\n                    <jats:italic>Gli3<\/jats:italic>\n                    -deficient mice. Our molecular and genetic analyses indicate that the size of fish fins is controlled by an ancient mechanism mediated by SHH-GLI signaling that appeared prior to the evolutionary appearance of paired fins. We also show that the key regulatory networks that mediate the expansion of digit progenitor cells in tetrapods were already in place in the fins of the last common ancestor between ray and lobe-finned fishes, suggesting an ancient similarity between distal fins and digits.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2100575118","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T16:25:50Z","timestamp":1636388750000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["The\n                    <i>Shh<\/i>\n                    \/\n                    <i>Gli3<\/i>\n                    gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-0337","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Letelier","sequence":"first","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Pablo de Olavide, and Junta de Andaluc\u00eda, Sevilla 41013, Spain;"},{"name":"Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago 8580745, Chile;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-3332","authenticated-orcid":false,"given":"Silvia","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo, Consejo Superior de Investigaciones Cient\u00edficas, Universidad Pablo de Olavide, and Junta de Andaluc\u00eda, Sevilla 41013, 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