{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:54:00Z","timestamp":1793321640968,"version":"4.5.0"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1017207"],"award-info":[{"award-number":["1017207"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["HL20948"],"award-info":[{"award-number":["HL20948"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","award":["Harold Amos Award"],"award-info":[{"award-number":["Harold Amos Award"]}],"id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006955","name":"Office of Extramural Research, National Institutes of Health","doi-asserted-by":"publisher","award":["K08"],"award-info":[{"award-number":["K08"]}],"id":[{"id":"10.13039\/100006955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,9,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 13% of adults and 10% of children worldwide. The inflammation seen in AD is driven by type 2 cytokines, including IL-4 and IL-13. We have an incomplete understanding about how these cytokines impact the epithelial barrier and drive AD pathology. Our study demonstrates that IL-4 and IL-13 promote androgen production and drive lipid abnormalities in sebocytes. These findings deepen our understanding of the impact of the immune system on the skin epithelium.<\/jats:p>","DOI":"10.1073\/pnas.2100749118","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T15:51:15Z","timestamp":1631634675000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":57,"title":["Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis"],"prefix":"10.1073","volume":"118","author":[{"given":"Chenlu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1781-8701","authenticated-orcid":false,"given":"Mahendran","family":"Chinnappan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-3403","authenticated-orcid":false,"given":"Courtney A.","family":"Prestwood","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-1854","authenticated-orcid":false,"given":"Marshall","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methinee","family":"Artami","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonne M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn M.","family":"Eckert","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-0289","authenticated-orcid":false,"given":"Goncalo","family":"Vale","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390;"},{"name":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane and Faculty of Health Sciences Brandenburg, 06847 Dessau, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390;"},{"name":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-7083","authenticated-orcid":false,"given":"Tamia A.","family":"Harris-Tryon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390;"},{"name":"Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.09.055"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.010"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15409"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12268"},{"key":"e_1_3_4_5_2","first-page":"83","article-title":"The challenge of managing atopic dermatitis in the United States","volume":"12","author":"Feldman S. R.","year":"2019","unstructured":"S. R. Feldman ., The challenge of managing atopic dermatitis in the United States. Am. Heal. Drug Benefits 12, 83\u201393(2019).","journal-title":"Am. Heal. Drug Benefits"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.012"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000110"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4624"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.012"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.11.006"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2012.08.010"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.017"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/19381980.2017.1375636"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.04.004"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.04.001"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2018.05.001"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22967"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0050"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1005"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00771.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12244.x"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.13.1.0221"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.07.010"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30804-0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.04.005"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(02)00370-X"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)81010-2"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2017.1298443"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0323"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01312.x"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.3.207"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.05.005"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1133426100"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005374"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.10.006"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.2100749118","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2100749118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:20:39Z","timestamp":1649838039000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2100749118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,14]]},"references-count":38,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2021,9,21]]}},"alternative-id":["10.1073\/pnas.2100749118"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2100749118","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,14]]},"assertion":[{"value":"2021-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2100749118"}}