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The BDNF\/TrkB signaling pathway plays a critical role in neuronal synaptic plasticity and neuronal survival. Since the BDNF\/TrkB pathway is reduced during aging and in AD human brains, we hypothesize that the crosstalk between these risk factors and BDNF\/TrkB deficiency may mediate AD pathologies. Our previous studies establish that the C\/EBP\u03b2\/\u03b4-secretase pathway plays a pivotal role in triggering the major AD pathologies. 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