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Dodds Fellowship from Princeton University","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,8,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Viruses rely on organelle remodeling for their replication and for the spread of infection. Alterations to mitochondrial functions and cellular metabolism are hallmarks of nearly all viral infections. However, how the widely spread HCMV remodels mitochondrial structure and function has presented a conundrum. It remained unclear how HCMV increases mitochondrial bioenergetics despite triggering mitochondrial fragmentation. Using a multidisciplinary approach, we address this question. We establish that the uncharacterized viral protein, pUL13, targets the mitochondria, interacts with the MICOS complex, and is sufficient for increasing oxidative phosphorylation during infection. Our findings provide evidence that viral pathogens have acquired mechanisms for manipulating cristae architecture and ETC function to achieve increased energy production and can have broad implications in understanding virus-driven pathologies.<\/jats:p>","DOI":"10.1073\/pnas.2101675118","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T15:35:37Z","timestamp":1628004937000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":37,"title":["The human cytomegalovirus protein pUL13 targets mitochondrial cristae architecture to increase cellular respiration during infection"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-3873","authenticated-orcid":false,"given":"Cora N.","family":"Betsinger","sequence":"first","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1247-4548","authenticated-orcid":false,"given":"Connor S.R.","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Hofstadter","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-0071","authenticated-orcid":false,"given":"Joel D.","family":"Federspiel","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-8105","authenticated-orcid":false,"given":"Clayton J.","family":"Otter","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre M.","family":"Jean Beltran","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-2458","authenticated-orcid":false,"given":"Ileana M.","family":"Cristea","sequence":"additional","affiliation":[{"name":"Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2015.02.038"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00042"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.12.040"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.631-641.2003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020132"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1500"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02123-09"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.655"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/14789072.2.6.881"},{"key":"e_1_3_4_10_2","first-page":"417","article-title":"Manifestations of human cytomegalovirus infection: Proposed mechanisms of acute and chronic disease","volume":"325","author":"Britt W.","year":"2008","unstructured":"W. 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