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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The oviduct is essential for female fertility due to its two main functions: transport and nourishment. While the nourishment role is mainly fulfilled by secretory cells, the relative contribution to the transport function by ciliated cells and smooth muscle cells remains controversial. Here, we show that functional motile cilia in the infundibulum are essential for oocyte pickup and transport, whereas motile cilia in the ampulla and isthmus regions of the oviduct facilitate gamete and embryo transport but are dispensable for female fertility. Knowledge derived from the present study may have important clinical implications in the areas including development of nonhormonal female contraceptives, understanding the cause of ectopic pregnancy and high-grade serous ovarian cancer, etc.<\/jats:p>","DOI":"10.1073\/pnas.2102940118","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T16:45:36Z","timestamp":1622047536000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["Oviductal motile cilia are essential for oocyte pickup but dispensable for sperm and embryo transport"],"prefix":"10.1073","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-7682","authenticated-orcid":false,"given":"Shuiqiao","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"},{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3988-0733","authenticated-orcid":false,"given":"Zhuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"},{"name":"Sections of Metabolic Diseases and Translational Genomics, The Lundquist Institute for Biomedical Innovation at Harbor\u2013UCLA Medical Center, Torrance, CA 90502;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Hennig","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huili","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"},{"name":"Sections of Metabolic Diseases and Translational Genomics, The Lundquist Institute for Biomedical Innovation at Harbor\u2013UCLA Medical Center, Torrance, CA 90502;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-9026","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89557;"},{"name":"Sections of Metabolic Diseases and Translational Genomics, The Lundquist Institute for Biomedical Innovation at Harbor\u2013UCLA Medical Center, Torrance, CA 90502;"},{"name":"Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30406-4_14"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0279"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod40.6.1131"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251215"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30231"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml012"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61935-9"},{"key":"e_1_3_4_8_2","first-page":"41","article-title":"Mechanics of ciliary transport","volume":"80","author":"Blake J. 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